Beyond the Chemical Imbalance Theory of Depression: An Interview with Prof. Joanna Moncrieff

This interview , conducted by Justin Garson, has been published in Psychology Today. It begins: “KEY POINTS In 2022, a large review led by Joanna Moncrieff showed the ‘serotonin theory of depression’ to be groundless. Her review puts into question our…
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Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory

This research paper has been published in JAMA Psychiatry. Key Points: Question: Is intrauterine exposure to selective serotonin reuptake inhibitors (SSRIs) and prenatal or postnatal depressive symptoms associated with brain morphologic trajectory in offspring? Findings: In this cohort study of 3198 mother-infant…
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Wishful thinking: antidepressant drugs in childhood depression

This paper from Anne Tonkin and Jon Jureidini has been published in the British Journal of Psychiatry. It begins: “The use of selective serotonin reuptake inhibitors (SSRIs) in children under 18 years old increased ten-fold (from 0.5 to 4.6 per 1000)…
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Risk of Suicidal Behaviors and Antidepressant Exposure Among Children and Adolescents: A Meta-Analysis of Observational Studies

This meta-analysis has been published in the journal Frontiers in Psychiatry. The summary is as follows: “Objectives: Although several studies have reviewed the suicidal risk of antidepressants, the conclusions remain inconsistent. We, therefore, performed a meta-analysis of observational studies to address the…
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Royal College of Psychiatrists’ Suicide Note

This blog post by Dr. David Healey contains a reply to Dr. Adrian James (President of the Royal College of Psychiatrists) concerning antidepressants and suicide. It begins: “24 April 2023  Dr Adrian James, President of the Royal College of Psychiatrists, has written…
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Methodological Flaws, Conflicts of Interest, and Scientific Fallacies: Implications for the Evaluation of Antidepressants’ Efficacy and Harm

This paper by Michael Hengartner has been published in the journal Frontiers in Psychiatry. The abstract says: “Background In current psychiatric practice, antidepressants are widely and with ever-increasing frequency prescribed to patients. However, several scientific biases obfuscate estimates of antidepressants’ efficacy…
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Celexa, Lexapro & the Death of Evidence-Based Medicine

This article has been published on the website of American legal firm Baum Hedlund Aristei & Goldman. It begins: “‘Oh, what a tangled web we weave. When first we practise to deceive!” From Walter Scott’s epic poem, Marmion. This is the story of…
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The hidden epidemic of sexual dysfunction which experts blame on SSRI antidepressants

Jo Macfarlane reports for the Mail on Sunday: SSRI antidepressants could cause ‘life-changing’ sexual problems experts say1 in 8 people were prescribed antidepressants in the past year according to statsBut they can cause serious side effects like libido drop and numb groin…
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Antidepressants Work Better Than Sugar Pills Only 15 Percent of the Time

This article by Adam Piore has been published in Newsweek magazine. It begins: “Five years ago Mark Horowitz seemed an unlikely skeptic of psycho-pharmaceuticals. He had been taking the popular antidepressant Lexapro virtually every day for 15 years. He was so…
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